咪康唑灌注在非侵袭性真菌性鼻窦炎手术后的应用

Application of miconazole irrigation in treatment of Non-Invasive fungal nasosinusitis

目的观察在鼻内镜治疗非侵袭性真菌性鼻窦炎手术后,鼻窦内注入硝酸咪康唑的临床效果。方法将非侵袭性霉菌性鼻窦炎患者(96例)随机分为两组,灌注组行鼻内镜手术后和手术后5d病变窦内注射硝酸咪康唑霜剂,对照组不采用灌注法。手术后经鼻内镜检查,随访18个月。结果灌注组有效率92.3%,复发7.7%;对照组有效率81.4%,复发率18.6%。统计学分析两组间有差异(P<0.05)。结论在非侵袭性真菌性鼻窦炎手术后实行病变鼻窦内灌注硝酸咪康唑可以提高治愈率,降低复发率。

[Objective] To investigate the effect of miconazole irrigation on treatment of non-invasive fungal nasosinusitis. [Methods] Patients were divided into two groups randomly. The patients in instilled group were practiced mieonazole irrigation in operation of FESS and on the fifth day after operations. The irrigation was insteded by anti-fungi drug washing in control group. All patients had been followed up for six months after FESS. [Results] The instilled group showed the higher valid rate （94.2%） and lower recurrent rate （5.8%） contrast to control group＇s valid rate （81.4%） and recurrent rate （18.6%）. There was difference between the two groups （P 〈0.05）. [Conclusions] Application of mieonazole irrigation in treatment of Non-Invasive fungal nasosinusitis can increase valid rate and reduce recurrent rate.