小细胞肺癌术前化疗的临床和病理学观察

Clinical and pathologic findinges of small cell lung cancer(SCLC) after preoperative chemotherapy

目的观察小细胞肺癌(SCLC)术前化疗对临床、病理学影响。方法32例SCLC术前化疗2个疗程,用EP方案(VP 16100m g/天,DDP 80m g/天),5天为1个疗程。化疗结束后20-30天手术,切除标本送病理学检查。结果手术切除率100%。术中见肿瘤附近纤维组织增生,肿大淋巴结包膜坚韧。病理学检查发现肿瘤消失、由纤维组织取代6例(18.7%);镜下少量癌组织残留5例(15.6%);少量生长活跃的癌组织13例(40.6%);癌组织轻度变性坏死或无明显改变8例(25.0%)。病理分期较临床分期提前,有利于手术切除。结论作为SCLC的综合治疗方法,术前化疗值得推荐。

Objective To review small cell lung carcinoma （SCLC） clinical and pathologic changed as a result of preoperative chemotherapy. Methods 32 SCLC patients underwent preoperative chemotherapy with routine quantity of EP. Results Their postoperative specimens were studied by fibrosis 6 cases （18.7%）;Scanty residual cancer tissues were seen by microscopy 5 cases （15.6%）;Degeneration and necrosis with fibrosis but active cancer tissues in small areas were found 13 cases （40.6%）; There was mild degeneration or no obvious changes 8 cases （25. 0%）. Conclusion This Kind of preoperative chemotherapy is recommended as one of integrative treatments to SCLC.