肺腺鳞癌1例报告并文献复习

One patient with lung adenosquamous carcinoma and literature review

目的探讨肺腺鳞癌(A SC)的临床表现、病理、影像学特点、治疗和预后。方法回顾性分析一例经病理诊断为肺A SC患者的诊断、治疗、预后特点。结果患者为40岁女性,临床表现为与其它非小细胞肺癌(N SCLC)相比无特殊性。病理特征为光镜下有腺癌和鳞癌两种细胞成分存在。肺影像学表现介于腺癌和鳞癌之间,以周围型肿块伴空洞形成为主要特征。经过积极的多学科治疗,术后生存期12个月,提示肺A SC恶性度高、预后差的特点。结论肺A SC作为N SCLC中独立的亚型,生物学行为和预后有自己的特点,治疗相应具有特殊性。早期诊断,综合治疗是获得长期生存的关键。

Objective To investigate the clinical manifestations, pathology, imageologh, treatment and prognosis of lung adenosquamous carcinoma （ASC）. Methods Combining with literature review, the characteristics of diagnosis, treatment and prognosis of one patient with lung ASC confirmed by pathology was analyzed retrospectively. Results The patient was 40 year old, female, having clinical manifestations of cough, sputum production, chest distress, low-grade fever. and coarse breath sound by chest examination. Compared with other non- small cell lung cancer （NSCLC）. there was no particularity. The pathological examination showed the presence of both squamous cell carcinomatous and adenocarcinomatous components. The radiologic findings of lung ASC were between adenocarcinoma and squamous cell carcinoma, characterized by a peripheral nodules accompanying cavitation, Although having had active multimodality therapy, the survival time was 12 months that indicated the high malignancy and poor prognosis of the disease, Conclusion As an independent subtype of NSCLC. the lung ASC has its own features of biologic behavior, of treatment and prognosis, We believe that it is key point for long term survival to have an early diagnosis and a comprehensive treatment,