氯沙坦加黄芪和灯盏花素注射液治疗糖尿病肾病的疗效观察

An Observation of Efficacy of Losartan Associated with Huangqi and Breviscapine Injection on Diabetic Nephropathy

目的探讨氯沙坦、黄芪和灯盏花素注射液治疗糖尿病肾病的疗效。方法将85例临床期和晚期糖尿病肾病患者随机分成治疗对照组和观察组,在常规饮食和药物治疗的基础上,分别给予氯沙坦和氯沙坦、黄芪和灯盏花素注射液治疗13周。结果两组患者血压明显降低(P<0.01);临床症状改善,肾功能损害减轻(P<0.05,P<0.01),且观察组的作用更为显著(P<0.05);血脂代谢改善(P<0.05)。结论氯沙坦和氯沙坦、黄芪和灯盏花素均可改善糖尿病肾病患者的临床症状,显著降低血压、减少蛋白尿,延缓肾病进展,且后者疗效更为显著。

Objective To study the effect of losartan associated with Huangqi injecta and Breviscapine injecta on diabetic nephropathy（DN）patients. Methods 85 cases of diabetic nephropathy patients with clinic renal failure were randomly divided into 2groups. In group A （n=33） the patients were received losartan（taken in morning）50mg/d,while in group B （n=30） received losartan （taken in morning） 50mg/d, associated with AMB 60ml and Breviscapine 40ml（both severally added in 0.9 % solution of sodium chloride 100ml itself together driped by vein, q. d）. Treatment courses lasted 13 weeks in both groups, the value of MAP, FPG,2hPG,TG, HDL,TC, urine protein/24h, Scr and BUN were detected for all patient before and after therapy, the data obtained from two groups were compared each other and analysed statistically. Results Detected outcomes indicated that , after therapy, the clinical symptom of all patients were more or less improved, the blood pressur（MAP）obviously droped（P〈0. 01） ,value of urine protein/24h, Scr,BUN,TGP（P〈0.05 ,P〈0.01）and TC （P〈0. 05）were all significantly reduced , but the HDL was enhanced （P〈0. 05）,and the efficacy in group B was more obvious than in group A （P〈0.01 vs P〈0. 05） （with the exception of BP）. Conclusion Losartan or losartan associated with AMB and Brevis-capine both improve the symptom of patients suffered from diabetic nephropathy, but the efficacy by using compound therapy is more obvious than losartan alone（P〈0. 05）.