尿粘康酸在苯的生物监测中的应用价值

Theapplicationvalueofurinaryt,t┐MAinbiologicalmonitoringofbenzeneexposure

为研究苯暴露的生物标志物，应用改进的高压液相色谱法检测了１２８名苯接触工人及４０名对照人群的尿粘康酸含量，同时测定了其尿酚含量。结果表明，当空气苯浓度为４１．４９ｍｇ／ｍ３时，接触工人的尿粘康酸含量为（５．４７±７．９４）ｍｇ／ｇＣｒ，尿酚为（３９．０９±４２．５９）ｍｇ／ｇＣｒ。对照人群的尿粘康酸含量为（０．１３±０．０９）ｍｇ／ｇＣｒ，尿酚为（１６．０１±１１．３３）ｍｇ／ｇＣｒ（均为肌酐校正值，ｘＧ±ｓ）。苯接触工人的尿粘康酸含量与所接触的空气苯浓度及尿酚含量呈良好的相关，相关系数分别为０．９１８７，０．８２０４。尿粘康酸在人群中本底值低，反映苯的内吸收情况比尿酚更特异、敏感，更适于低浓度苯暴露的生物监测。

Theurinarytrans,trans-muconicacid(t,t-MA)in128workersexposedtobenzeneweredetectedbyamodifiedHPLCmethod.Theresultshowedthatthegeometricmeansofindividualairbenzeneconcentration,correspondingurinnaryt,t-MAandphenolcontentswere41.49mg/m3,(5.47±7.94)mg/gCrand(39.09±42.59)mg/gCrrespectively.Thegeometricmeansoft,t-MAandphenolin40unexposedpeoplewere(0.13±0.09)mg/gCrand(16.01±11.13)mg/gCrrespectively.Goodcorelationswerefoundbetweenurinaryt,t-MAandairbenzeneorbetweent,t-MAandphenolinexposedworkers(r=0.9187,or0.8204,P<0.01).Thebackgroundlevelsoft,t-MAinnon-ex-posedworkerswereratherlow.Itissuggestedthaturinaryt,t-MAmightbeeasier,morepracticalandsuitablethanurinaryphenolforbiologicalmonitoringinlowbenzeneexposure.