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多糖单克隆抗体的研究进展 被引量：6

Advances in the Research on the Monoclonal Antibody against Polysaccharides
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摘要 介绍了制备多糖抗原的两种方法及影响多糖免疫原性的因素,并综述了检测多糖单抗的酶联免疫吸附测定法的最新进展以及多糖单克隆抗体在菌体亚型分类、抗原表位研究、疾病诊断治疗和多糖药代动力学研究等方面的应用情况。 studies of epitope, the diagnosis and treatment of infection and disease, and the developing pharmacokinetics of polysaccharides were also reviewed.
作者 谢陶吟 赵虎 高向东
机构地区 中国药科大学生命科学与技术学院
出处 《药学进展》 CAS 2005年第9期391-397,共7页 Progress in Pharmaceutical Sciences
基金 国家自然科学基金资助项目(30472061)
关键词 多糖 单克隆抗体 偶联物 拟糖肽 Polysaccharides Monoclonal antibody Conjugation Peptide mimotope
分类号 R392.1 [医药卫生—免疫学]
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参考文献37

  • 1陈騉,辛现良,耿美玉,朱建春,杨明,李勇.海洋硫酸多糖类药物聚甘古酯单克隆抗体的制备及其特性研究[J].药学学报,2003,38(1):23-26. 被引量：4
  • 2Seppala I, Makela O. Antigenicity of dextran-protein conju-gates in mice. Effect of molecular weight of the carbohydrate and comparision of two modes of coupling[J]. J Immuol, 1989,143(4):1259-1264.
  • 3Libon C, Haeuw J F, Crouzet F, et al. Streptococcus pneu-moniae polysaccharides conjugated to the outer membrane protein A from Klebsiella pneumoniae elicit protective antibodies[J]. Vaccine, 2002,20 (17): 2174-2180.
  • 4Tomasic J, Spoljar B, Ljevakovic D, et al. Preparation of novel conjugates involving immunomodulating peptidoglycan monomer[J]. Prep Biochem Biotechnol, 1999,29(4):385-401.
  • 5Lees A, Nelson B L, Mond J J, et al. Activation of soluble polysaccharides with 1-cyano-4-dimethylaminopyridinium tet-rafluoroborate for use in protein-polysaccharide conjugate vaccines and immunological reagents[J]. Vaccine, 1996,14(3):190-198.
  • 6Bystricky S, Machova E, Bartek P, et al. Conjugation of yeast mannans with protein employing cyanopyridinium age(CDAP)-an effective route of antifungal vaccine preparation[J]. Glyco J, 2000,17(10):677-80.
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药学进展
2005年 第9期

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