人乳头状瘤病毒与喉癌、喉内翻性乳头状瘤发病的关系

Pathogenic relation between human papilloma virus and inverted laryngeal papilloma

应用聚合酶链反应(PCR )法检测人乳头状瘤病毒(HPV)抗原.并在透射电镜下查找NPV颗粒 在13例喉内翻性乳头状瘤的标本中.有7例找到HPV颗粒.8例HPV抗原阳性:其中3例喉内翻性孔头状瘤恶变的际本中2例找到HPV颗粒已抗原阳性.证明喉内翻性乳头状瘤发病及其癌变与HPV密切相关.

We exa mined 13 cases of inverted laryngeal papilloma .including cases that turned malignant squamous cell carcinomas ,to find antigen of HPV by PCR,as well as particles of HPV under transmission electron microscope. As a result. we found 7 cases with HPV particles and 8 cases with HPV antigen positive. Among the 3 malignant cases,we found HPV particles and HPV antigen positive in two cases. We can conclude that HPV has a close relation with laryngeal carcinoma and inverted papillomas.