摘要
为探讨移植肾排斥反应与血小板活化指标的关系,应用抗人活化血小板GMP-140(α-颗粒膜蛋白)特异单克隆抗体Sz-51(苏州-51),检测68例肾移植患者外周血血小板表面及血浆GMP-140含量;同时采用放射免疫法测定血浆TxB2(血栓烷B2)含量。术后肾功能正常者GMP-140及TxB2略有升高;发生急慢性排斥反应时两者均显著升高(P<0.001),排斥逆转或移植肾切除后逐渐下降。发生环孢素中毒者其含量无明显变化(P>0.05)。提示移植肾排斥与体内血小板活化有关,活化指标GMP-140、TxB2检测对早期诊断肾移植后排斥反应及环孢素中毒具有一定的临床价值,是监测移植肾排斥反应的一个较灵敏的生物学指标。
GMP-140 and TxB2 levels were determined in 68 renal allograft recipients.These levels were found to be significantly higher in patients with acute or chronic renal allograft rejection than those in patients with cyclosporin A nephrotoxicity or in activation in vivo and the detection of GMP-140 and TxB2 was of value in the early diagnosis of rejection and cyclosporin A nephrotoxicity in renal transplant recipients.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1996年第7期399-401,共3页
Chinese Journal of Urology
关键词
肾移植
血小板
移植免疫学
活化指标
Transplantation Kidney Blood platelets Transplantation immunology