太原地区1400例习惯性流产夫妇的细胞遗传学研究

The study of molecular genetics in patients with habital abortion.

目的探讨夫妻双方染色体异常与习惯性流产的关系。方法回顾性分析1400例前来遗传咨询的习惯性流产夫妇的染色体。结果1400例习惯性流产夫妇中,染色体异常73例,占5.21%,其中常染色体异常发生率女性显著高于男性,性染色体异常发生率男性显著高于女性。结论夫妻双方染色体异常与习惯性流产有关,对习惯性流产夫妇进行细胞遗传学检查,不仅有利于明确病因,而且有利于生育指导。

OBjective ： To study the relation between abnonnal chromosome and patients with early habital abortion. Methods：a retrospective study was performed to analysis of chromosome from 1400 cases with early habital abortion . Results：Abnormalities were found in 73 cases with detective rate of 5.21% ,woman were significantly higher than man in autosomal disease ,were less than man in sex chromosomal disease. Conclusion ： Cytogenetic chromosome karyotypic analysis is useful in habital abortion , it is not only to assist analysis the origin of the disease , but also to supply important references for clinical therapy .