竹叶黄酮的抗氧化性及其心脑血管药理活性研究进展

ADVANCES IN STUDIES ON ANTIOXIDATIVE ACTIVITY AND CARDIO-CEREBROVASCULAR PHARMACOLOGY OF BAMBOO-LEAF-FLAVONOIDS

介绍了竹叶黄酮的抗氧化性及其心脑血管药理活性相关的研究进展。1)体内体外实验表明,竹叶黄酮具有清除自由基、抗脂质过氧化、提升体内抗氧化水平的作用;2)动物试验和临床试验表明,竹叶黄酮能显著降低动物及人体的血清甘油三酯含量,升高高密度脂蛋白胆固醇含量;3)药理研究表明,竹叶黄酮具有抗整体动物缺氧的作用、能有效扩张冠脉血管、增加冠脉流量,增加心肌收缩力、明显改善心肌缺血及缩小心梗范围,降低血小板聚集程度、有效抑制凝血和血栓形成,对脑缺血有一定的保护作用。竹叶黄酮具有作为防治心脑血管疾病的天然药物和膳食补充剂开发的潜力。

The advances in researches on antioxidative activities and pharmacologic activities of bamboo-leafflavonoids （EOB-f） against cardio-cerebrovascular diseases were reviewed. 1 ） Experiments in vitro and vivo showed that EOB-f could scavenge radicals, prevent lipid peroxidation and increase the level of antioxidation in vivo; 2 ） Animal tests and clinic tests showed that EOB-f could significantly depress the triglyceride level and elevate the high density lipoprotein cholesterol level in serum of animal and human; 3 ） Pharmacological experiments revealed that EOB-f could efficiently expand coronary artery and increase its flux, improve the blood supply of heart muscle and shrink the area of myocardial infarction, decrease the congregation of blood platelet and inhibit thrombosis, and keep brain tissue from blood shortage. In short words, EOB-f may be a kind of promising natural products for the develop- ment of medicine and dietary supplement against eardio-cerebrovascular diseases.