血脂水平与轻度认知障碍的关系研究

The Relationship of Serum Lipid and Mild Cognitire Impairment

目的探讨血脂、脂蛋白、载脂蛋白(Apo)及脂蛋白(a)[Lp(a)]在轻度认知障碍(MCI)发病中的作用。方法检测30例(MCI)组血脂7项指标含量,并与对照(NC)组的检测结果进行比较。结果MCI组的TC、LDL-C、ApoB、Lp(a)明显高于NC组,(P<0.01),而其ApoA/B明显低于NC组(P<0.01)。结论MCI患者存在脂质代谢紊乱,提示其可能是导致MCI并使MCI转变为老年性痴呆(AD)的危险因素之一。

Objective To investigate the role of serum lipids;lipoprotein apolipoprotein （Apo） and lipoprotein（a） in the pathogenicity of mild cognitive impairment （MCI）. Methods The seven indices of serum lipids in 30 patients with MCI （patient group） and 30 healthy persons （sontrol group ） were measured and com- pared. Results TC, LDL-c 、 Lp （a） of MCI patients were significantly higher than those of control group （P〈 0.01） and their ApoA/B was significanlty lower than that of latter （ P 〈 0.01）. Conclusion MCI patients with high lipoprotein indicate one of the risk factors leading MCI and changing from MCI to AD.