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慢性脑缺血大鼠海马区NMDAR1表达的实验研究 被引量：3

Experimental Study on the Expression of NMDAR1 in Hippopcampus after Chronic Cerebral Hypoperfusin in Rats
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摘要 目的观察慢性脑缺血时认知相关分子N-甲基-D-天门冬氨酸受体(NMDAR1)mRlNA表达的变化。方法采用双侧颈总动脉永久性结扎(2-VO)制作慢性脑缺血模型。12只雄性大鼠随机分为正常对照组(6只)和手术组(6只)。术后2个月处死动物,取大鼠海马组织,RT-PCR检测NMDAR1的mRNA水平。结果手术组较正常对照组NMDAR1水平下降(P<0.05)。结论大鼠海马区NMDAR1表达下调可能是慢性脑缺血所致血管性认知功能障碍的分子机制之一。 Objective To observe the change of NMDARI expression in the hippocampus of rats suffering from chronic cerebral hypoperfusion. Methods Chronic cerebral hypoperfusion was created by a permanent, bilateral occlusion of the common carotid arteries （2-VO） of adult rats. Twelve male rats were divided randomly into two groups： six in the control group, six in the operative group. Then the rats were sacrificied on the two months after operation, and the mRNA of NMDARI in hippocampus was detected with RT-PCR. Results The mRNA level of NMDARI of operative group was significantly decreased compared with that of control group. Conclusion Chronic cerebral hypoperfusion induced the decrease of NMDARI expression of hippocampus, which may contribute to vascular cognitive impairment.
作者 熊丽 章军建 周红伟
机构地区 武汉大学脑血管病研究中心 武汉大学中南医院神经内科
出处 《医学新知》 CAS 2005年第3期33-35,共3页 New Medicine
基金 国家自然科学基金(30270483)
关键词 慢性脑缺血 NMDAR1 认知功能障碍 缺血大鼠 海马区 N-甲基-D-天门冬氨酸受体 实验研究 血管性认知功能障碍 mRNA表达 正常对照组 chronic cerebral hypoperfusion. NMDAR1： cognitive impairment
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献10

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二级参考文献17

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共引文献1

同被引文献51

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二级引证文献9

医学新知
2005年 第3期

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