P53、Ras基因突变及HPV感染与膀胱癌的关系

P53,Ras genes,HPV and bladder carcinoma

应用分子生物学方法检测３２例膀胱移行上皮癌中Ｐ５３、Ｋ－ｒａｓ、ＨＰＶ基因，发现有３４．４％的膀胱癌Ｐ５３基因突变，２１．９％膀胱癌Ｋ－ｒａｓ基因突变，６．３％膀胱癌ＨＰＶ阳性。说明膀胱移行上皮癌的发生与Ｐ５３、Ｒａｓ基因突变及ＨＰＶ感染有关。膀胱癌的发生是多种基因的变化通过多种途径引起的。

cases of transitional cell carcinoma of bladder were detected for P53,K-ras genes and HPV using molecular biologic techniques.P53 mutation was observed in 34.4%,K-ras mutation in 21.9% and HPV-positive in 6.3%.The results revealed that bladder carcinoma was related to the mutation of P53 and ras genes and to the HPV infection.It was postulated that the pathogenesis of bladder carcinoma was related to the change of various genes through different pathway.