双氯灭痛直肠给药治疗下尿路术后并发的膀胱无抑制性收缩

Rectal diclofenac for the management of postoperative uninhibited contraction of bladder

对３０例下尿路术后并发的膀胱无抑制性收缩患者按随机化顺序，采用单盲交替给药法，分别用自制双氯灭痛胶浆剂１００ｍｇ直肠给药和异搏定１０ｍｇ静注进行治疗。症状改善后复发或未改善者２小时后交叉用药。结果显示：双氯灭痛治疗总有效率为８８．５％，异搏定总有效率７５％，两者比较差异无显著性（ｐ＞０．０５），但双氯灭痛显效率和作用持续时间明显优于异搏定（Ｐ＜０．０５，Ｐ＜０，００１），且无明显副作用。因此认为双氯灭痛是一种治疗膀胱无抑制性收缩的较理想用药。

Rectal diclofenac mucilloid(100mg)or intravenous isoptin(10mg)was given to 30 patients after lower urinary tract surgery for the relief of uninhibited bladder contraction on a single blind crossover trial basis.Alternative use of the two agents was given again 2 hours later if necessary.The total effective rate of rectal diclofenac was 88.5% and that of intravenous isoptin 75.0%(P>0.05).The mean effect-lasting time of rectal diclofenac was 25.5 ±12.3h being significantly higher than that of intravenous isoptin(P<0.001).No significant adverse side reaction was observed.Rectal diclofenac was claimed to be the better agent for the relief of postoperative uninhibited bladder contraction.