IA期非小细胞肺癌的肿瘤大小对其预后的影响

Impact of Tumor Size on Survival in Stage IA Non-Small Cell lung Cancer

目的探讨IA非小细胞肺癌肿瘤的大小对预后的影响。方法回顾地分析自1995年1月至2003年12月．我院胸外科手术治疗IA非小细胞肺癌142例，Kaplan—Meier生存曲线统计不同肿瘤大小的生存率，并对其发病的年龄、性别、病理类型、肿瘤的大小、手术方式及是否接受放化疗进行Cox回归比例风险模型多因素分析。结果全组病变≤2．0cm60例．2．1～3．0cm 82例。全组3年生存率为80．53％；5年生存率为64．50％。其中病变≤2．0cm5年生存率为88．00％和74．09％．病变2．1～3．0cm为74．79％和57．14％。单因素分析及多因素分析，肿瘤的大小均为独立的预后因素。结论肿瘤大小作为IA期非小细胞肺癌的独立预后因素，要求我们要进一步提高影像学的诊断水平．使病人获得更早期的治疗。

Objective To explore the impact of tumor size on prognosis in stage IA non-small cell lung cancer. Methods We analysed retrospectively 142 consecutive, surgically treated patients with pathologic stage IA non-small cell lung cancer. Kaplan-Meier survival curve was performed to estimate the survival rate of different size of tumor, and also a Cox proportional hazard regression model was used to make multivariate analysis of the incidence of age, gender, pathologic type, tumor size and chemoradiotherapy. Result In this group, patients with tumor size less than 2.0 cm occurred in 60 eases, and between 2.1 cm to 3.0 cm in 82 eases. The overall survival rate in 3-year and 5-year were respectively 80.53% and 64.50%, in which tumor size less than 2.0 cm were 88.00% and 74.09%, tumor size between 2.0 cm to 3.0 cm 74.79 % and 57.14%, respectively. In both univariate and multivariate analysis, the tumor size was an independent prognosis factor for survival. Conclusions Owing to the tumor size is an independent prognosis factor, the diagnosistie level in imageology should be improved so as to treat the patients at early stage.