HER2、HER1在非小细胞肺癌中过度表达及其临床意义

Study on detecting overexpression of HER2 and HER1 in NSCLC and their clinical significance

目的检测人体表皮生长因子受体2(HER2)与人体表皮生长因子受体1(HER1)在非小细胞肺癌中的表达,研究其过度表达与肺癌临床病理的关系。方法采用免疫组化(SP)法检测有5年随访资料的58例肺癌(32例鳞癌和26例腺癌)组织中HER2与HER1的表达。结果HER2、HER1、HER2和HER1双表达(HER2+1)表达率分别为56.9%、63.8%、31.0%; HER2、HER1、HER2+1的过度表达与肺癌的淋巴结转移、TNM分期呈正相关,与术后5年生存率呈负相关。结论HER2、HER1的过度表达不是肺癌形成过程中的早期现象,而是肺癌发生发展过程中的晚期现象;HER2、HER1、HER2+1过度表达与肺癌患者术后预后呈负相关,是肺癌患者预后的标记指标之一。

Objective To detect the expression oi human epidermal growth factor receptor-2 （HER2） and human epidermal growth factor（HER1） in non-small cell lung cancer （NSCLC） and investigate the relationship between their overexpressions and the clinical pathology of lung cancer. Methods Fifty-eight cases of paraffin embedded tissues from lung cancer （32 cases of squamous cell cancer and 26 cases of adenocarcinoma） with 5 years of follow-up information were detected for the expressions of HER family by means of Immunohistochemical assay. Results HER2, HER1, HER2＋ 1 were over-expressed in lung cancer in 56.9%, 63.8% and 31. 0%, respectively. The over-expression Of HER2, HER1, HER2＋1 in lung cancer positively correlated with lymph node metastasis,TNM staging and negatively correlated with five year survival after operation. Conclusion The overexpressions of HER2 and HER1 is not the early expressions of the growth of lung cancer but expression of the growth of lung cancer at advanced stages. HER2, HER1 and HER2＋1 overexpressions might be an important prognostic indicator of the survival of lung cancer after operation.