血清半胱氨酸蛋白酶抑制剂C与平均肾小球体积的相关性研究

Study on the correlation between serum cystatin C and mean glomerular volume

目的研究血清半胱氨酸蛋白酶抑制剂C(CysC)与平均肾小球体积(MGV)的相关性,以寻求对肾小球滤过率表达的理想检验指标。方法应用颗粒增强免疫透射比浊法测定31例不同肾脏疾病肾活检患者的血清CysC浓度,同时用体视学方法测定MGV。结果CysC与MGV明显相关(r=0.715,P<0.01),与内生肌酐清除率(Ccr)显著相关(r=-0.819,P<0.01);Ccr与MGV也明显相关(r=-0.609,P<0.01);血肌酐(Cr)与MGV之间的r为0.546(P<0.05)。结论血清CysC与MGV的改变明显相关。

Objective To study the correlation between serum cystatin C （Cys C ） and mean glomerular volume （MGV） ,and seek for an ideal test marker of glomerular filtration rate. Methods Serum Cys C of 31 patients with different renal disease was determined by particle-enhanced immunoturbidimetry method, MGV was measured by stereologic method. Results The level of serum Cys C was well correlated with MGV（ r =0.715 ,P 〈 0.01 ） and creatinine clearance rate （Ccr） （ r = - 0.819, P 〈 0.01 ）. The correlation of Ccr and MGV was also good（ r=- 0.609, P 〈 0.01 ）. The r value of serum creatinine and MGV was r=0.546 （ P 〈 0.05 ）. Conclusions There was very good correlation between Cys C and MGV.