摘要
目的研究冠心病患者血浆B型钠尿肽(BNP)水平与左心室收缩功能的关系.方法用免疫发光法检测30名正常对照者与69例冠心病患者血浆BNP水平,通过纽约心脏病协会心功能分级标准(NYHA)及超声心动图结果对冠心病患者心功能分级.结果对照组、心功能Ⅰ～Ⅱ级组及心功能Ⅲ～Ⅳ级组的BNP水平分别为(31.56±21.48) μg/L、(105.52±91.77) μg/L和(433.18±378.03)μg/L,3组差异均有非常显著性(P<0.001).冠心病患者BNP水平与左室射血分数(LVEF)呈负相关(r=-0.70,P<0.001),其中LVEF≤40%亚组BNP水平显著高于LVEF>40%亚组(P<0.01).结论血浆BNP水平能反映冠心病患者左心室收缩功能,该指标对早期心功能不全患者的检出、心力衰竭程度的评判等具有重要的临床价值.
Objective To study the relationship between the plasma level of B-type natriuretie peptide（BNP） and the left ventrieular function in patients with coronary heart disease. Methods BNP levels in plasma of 30 nomal controls and 69 patients with coronary heart disease were measured by ehemilumino-immunoassay. The ventrieular function was measured by NYHA and colored doppler eehoeardiography. Results The BNP concentrations in control group, ventrieular function （ Ⅰ - Ⅱ ） group and ventrieular function （ Ⅲ-Ⅳ ） group were （ 31.56 ± 21.48） μg/L, （ 105.52 ± 91.77） μg/L and （433.18 ± 378.03 ）μg/L respectively. There was statistical significance among these groups（P 〈 0. 001 ）. The levels of plasma BNP and the left ventrieular ejeetive fraction （LVEF） had a significant negative correlation （r = -0.70, P 〈0. 001 ）. BNP levels of LVEF≤40% subgroup were significantly higher than those of LVEF 〉 40% subgroup （P 〈0.01 ）. Conclusions BNP level reflects the left ventrieular function in patients with coronary heart disease. The determination of BNP has important value in the diagnosis of early ventrieular dysfunction and the evalua- tion of the severity of cardiac failure.
出处
《检验医学》
CAS
北大核心
2005年第5期434-436,共3页
Laboratory Medicine
