巨大儿、宫内发育迟缓儿的脐血胃泌素、生长激素水平变化

Study on the level of gastrin and growth hormone in the cord blood of newborn with fetal macrosomia and intrauterine growth restriction

目的研究巨大儿、宫内发育迟缓(IUGR)患儿的发生与脐血中胃泌素(Gas)、生长激素(GH)的关系,以探讨内分泌环境对胎儿生长发育的影响。方法检测正常儿组(71名)、IUGR组(31例)和巨大儿组(28例)的脐血Gas、GH水平。结果正常儿组中,经择期剖宫产的研究对象与经阴式分娩的相比,脐血Gas水平显著降低(P<0.01),脐血GH水平明显升高(P<0.05);采用阴式分娩的研究对象中,IUGR患儿脐血GH水平显著高于正常儿,巨大儿脐血Gas水平显著低于正常儿。结论胎儿体重和分娩方式对脐血Gas和GH水平有影响。

Objective To investigate the levels of gastrin （Gas） and growth hormone（GH） in the cord blood of newborn with fetal and intrauterine growth restriction（IUGR） and to assess the effects of the endocrinology environment on macrosomia and IUGR. Methods The levels of Gas and GH in the cord blood were measured in the normal group （ n = 71 ）, IUGR group （ n = 31 ） and macrosomia group （ n = 28 ）. Results In the normal group, the level of Gas in cesarean section was markedly lower, and the level of GH was markedly higher than those in vaginal delivery. In vaginal delivery cases, the level of Gas in fetal macrosomia group was obviously lower than that in normal group, and the level of GH in IUGR group was markedly higher than that in nomal group. Conclusions The levels of Gas and GH in the cord blood are influnced by fetal birth weight and delivery pattern.