腹水综合征患鸡肺小动脉肌型化及维生素C对其作用

Effect of vitamin C supplementation on muscularization of pulmonary arterioles in broilers with ascites syndrome

350羽AA商品肉鸡随机分为A、B、C、D和E组,常规饲养。14日龄后A组鸡正常对照,而B、C、D和E组鸡舍温按每日1-2℃由25℃逐步降至12℃,同时D和E组在日粮中按1.5 mg/kg的剂量添加甲状腺素T3以诱发肉鸡腹水综合征(AS);C和E组在日粮中以500 mg/kg的剂量添加维生素C(Vc)以观察其效果。结果表明:低温和T3能显著增加AS发病率、红细胞压积(PCV)值和厚壁外周血管百分率(%TWPV)(P<0.01);同时,分别在低温或低温加T3的条件下,添加Vc能显著抑制AS发病率和%TWPV的上升(P<0.01),但未能改变肉鸡的PCV值(P>0.05)。从而揭示了Vc对低温和T3诱发的肉鸡AS和肺微细血管肌型化有预防作用。

Throe hundred and fifty 1 - day - old AA commercial broilers were divided randomly into control （ Group A ） and four experimental groups （ B,C.D and E） . Broilers in different experimental groups and group A were fed a normal diet before 14 days of age. In different experimental groups, broilers were subjected to a change of temperature by lowering 1 - 2 ℃ per day from 25 ℃ （ day 14 ） down to 12 ℃ , and then maintained at this ambient temperature until 7 weeks of age. At the same time, 1.5 mg/kg 3,3,5 - triiodothyronine （ T3 ） in the diet was added to in groups D and E in order to in- duce ascites syndrome （ AS ） , and 500mg/kg ascorbic acid （ Vitamin C ） in the diet was added to in groups C and E with the purpose of decreasing the incidence of AS. The result indicated that the lower ambient temperature and dietary T3 significantly ineroased AS incidence, packed cell volume （ PCV ） and the percentage of thick - walled peripheral lung vessels （ % TWPV ） （ P 〈 0.01 ）. In the same times, vitamin C supplementation, in the cool environ- mental temperature or dietary T3, significantly reduced AS incidence and % TWPV （ P 〈 0.01 ） , but didnt change PCV （ P 〉 0.05 ）. It might be concluded that vitamin C supplementation could prevent broiler AS induced by cool or dietary T3 and muscularization of pulmonary arterioles in broilers.