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含NURR1基因腺病毒对神经干细胞分化的影响 被引量：1

Adenovirus with NURR1 gene affecting on differentiation of neural stem cell
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摘要 目的含NURR1基因的重组腺病毒对神经干细胞分化的影响。方法免疫组化观察转染腺病毒后C17·2神经干细胞后分化效率。结果含NURR1基因的重组腺病毒可使C17·2神经干细胞分化后近76%细胞表现为神经元显型。结论含NURR1基因的腺病毒能明显的提高神经干细胞的分化效率。 Objective To observe the differentiation of neural stem cell infected by adenovims with NURR1 gene （Ad- NURR1 ）. Methods To observe the differentiation of C17.2 neural stem cell inffected by Ad - NURR1 using an immunohistochemistry method. Results Seventysix percent cells showed phaenotype of neuron after C17.2 neural stem ceils infected by Ad - NURR1 differentiated. Conclusion Ad - NURR1 could promote effective differentiation ratio of neural stem cells.
作者 李庆军 黎祥喷 刘军 赵东晖 苗旺 邢诒刚
机构地区 广东东莞市人民医院 中山大学附属第二医院神经内科 郑州大学第二附属医院神经内科
出处 《实用神经疾病杂志》 2005年第5期7-8,共2页
基金 国家教育部博士点基金资助 编号D002003003
关键词 NURR1基因 腺病毒 神经干细胞 细胞分化 分化效率 Parkinson disease Neural stem cell Adenovirus NURR1
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献7

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同被引文献14

  • 1黄仕雄,刘军,肖颂华,沈庆煜,刘运林,刘中霖,贺峰,邢诒刚.Nurr1基因转染人脐血间充质干细胞诱导分化为多巴胺能神经元的实验研究[J].中华神经医学杂志,2007,6(3):238-240. 被引量：1
  • 2王晶,李志忠,徐茅,迟作华.人脐血间质干细胞一般特性及其多向分化潜能[J].中山大学学报（医学科学版）,2007,28(4):418-421. 被引量：2
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  • 10Low CB,Liou YC,Tang BL.Neural differentiation and potential use of stem cells from the human umbilical cord for central nervous system transplantation therapy[J].J Neurosci Res,2008,86(8):1670-1679.

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实用神经疾病杂志
2005年 第5期

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