摘要
目的含NURR1基因的重组腺病毒对神经干细胞分化的影响。方法免疫组化观察转染腺病毒后C17·2神经干细胞后分化效率。结果含NURR1基因的重组腺病毒可使C17·2神经干细胞分化后近76%细胞表现为神经元显型。结论含NURR1基因的腺病毒能明显的提高神经干细胞的分化效率。
Objective To observe the differentiation of neural stem cell infected by adenovims with NURR1 gene (Ad- NURR1 ). Methods To observe the differentiation of C17.2 neural stem cell inffected by Ad - NURR1 using an immunohistochemistry method. Results Seventysix percent cells showed phaenotype of neuron after C17.2 neural stem ceils infected by Ad - NURR1 differentiated. Conclusion Ad - NURR1 could promote effective differentiation ratio of neural stem cells.
基金
国家教育部博士点基金资助
编号D002003003