依那普利治疗慢性心功能不全疗效观察

Clinic observation of Enalapril in chronic congestive heart failure

目的:探讨依那普利治疗慢性心功能不全的疗效及其安全性.方法:NYHA心功能分级Ⅱ～Ⅳ级的住院患者140例,其中冠心病86例、扩张型心肌病14例、风心病14例、高血压心脏病24例,按入院顺序随机分为两组.对照组给予利尿、扩血管治疗,心功能Ⅳ级时加用洋地黄类药物,观察组在此基础上加用依那普利,剂量从2.5 mg/d开始,渐增到10 mg/d,递增周期为1～2周.随访观察1～6个月.结果:对照组及治疗组治疗1个月、6个月,二组治疗后的左室射血分数(LVEF)、左室短轴缩短率(FS)、每搏排血量(SV)、心输出量(CO)、心脏指数(CI)均较治疗前有明显改善,但观察组明显优于对照组,二组差异有统计学意义.结论:依那普利可作为治疗慢性心功能不全的重要治疗药物.

Objective ： To evalution of the efficacy and safety of enalapril in chronic congestive heait failure（CHF） .Methods： The 140 patients with （NYHA） heart functionⅡ-Ⅳ grade divided into two group according to hospital admission at random, 86 patients with coronary heart diseases , 14 patients with dilated cardiomyopathy, 14 patients with rheumatic heart , 24 patients with hyper-tensive heart disease among them. control group given therapy such as diuresis, extension blood vessel, patient with heart function IV added to digitaloid drugs, observe group added to enalapril at the base, 2.5 mg/d in dose at start, gradually increase to 10 mg/d, 1 to 2 weeks at increase period, 1 to 6 months follow-up visit. Results： After 1 to 6 months treatment, there are obviously improvement in LVEF, FS,SV, CO, CI before treatment between two groups, but there was most remarkable in two groups （ P 〈 0.05）. Con- clusion ： Enalapril is an important drugs with treatment to chronic congestive heait failure.