甘糖酯、胰岛素对糖尿病患者体外红细胞变形能力的影响

EFFECTS OF PGMS AND INSULIN ON ERYTHROCYTE DEFORMABILITY IN PATIENTS WITH DIABETES MELLITUS

将１２例糖尿病病人的红细胞分别与胰岛素、甘糖酯体外共同孵育２４小时，观察孵育前后红细胞滤过指数的变化及药物对其影响。结果显示单纯孵育后红细胞滤过指数明显升高（ｐ＜０．０１）；与胰岛素共同孵育者红细胞滤过指数亦增高（Ｐ＜０．０１），但较前者低（ｐ＜０．０１）；与甘糖酯共同孵育者，红细胞滤过指数较孵育前降低（Ｐ＜０．０１）。说明胰岛素及甘糖酯对红细胞变形能力有保护作用，特别是后者对于治疗糖尿病患者并发的血管病变具有重要意义。

The present study on 12 cases disclosed that the erythrocyte deformability(ED)ofpatients with diabetes mellitus(DM) was significantly lower than norrnol control.After incubating thepatient's erythrocyte with Proplene Glycol Mannituse Sulfate(PGMS) and insulin,the ED was signifi-cantly higher than that of incubated without drug, PGMS was more efficious.The result indicated that PGMS and insulin have high value in improving the microcirculation and treatment the microangipathyin patients with DM.