正交试验优选强肝利胆口服液提取工艺

Optimization of Preparation Technics for Liver-strengthening Cholagogue Oral Preparations by Orthogonal Test

目的:筛选强肝利胆口服液的最佳提取工艺。方法:采用正交设计试验,以总黄酮含量为指标,考察加水量、煎煮时间、煎煮次数、醇沉浓度4种因素对提取结果的影响。结果:最佳提取工艺为10倍药材量的水、煎煮时间60min、醇沉浓度50%、煎煮次数2次。结论:该工艺所制成品澄明度好,含量稳定。

OBJECTIVE： To optimize the extraction technics of liver-strengthening cholagogue oral preparation. METHODS： The effects of the four factors - the quantity of the added water, the decoction time, the decoction times and the alcohol precipitation concentration on the extraction results were determined with content of total flavonoids taken as index. RESULTS： The best extracting condition was the following, the amount of the added water was 10 times that of the medicinal materials, the decoction duration was 60min, the alcohol precipitation concentration was 50% and the decoction was carried out twice. CONCLUSION： The preparation under this technics is of high clarity and stable contents.