摘要
目的测定月桂酰吲达帕胺的电离常数(pKa)及分配系数。方法采用酸碱滴定法测定各不同体积比的丙酮-水溶液中药物半中和点时的pH值作为药物在该体积比的丙酮-水溶液中的pKa值,再外推至纯水中药物浓度无限稀释时的pKa值;采用HPLC配合摇瓶法测定药物的分配系数。结果月桂酰吲达帕胺的pKa为3.87,lgP值为3.190。结论月桂酰吲达帕胺为弱酸性亲脂性药物。
Objective To determine the ionization constant and partition coefficient of lauroyl indapamide. Methods The ionization constant was determined with acid-basle titration in acetone/water solutions with different ratios, the pH at half neutralization point was regarded as pKa, the value to infinite diluted in pure water was explored and the lgP was determined with bottle-shaking method by HPLC. Results The pKa and lgP of lauroyl indapamide were 3.87 and 3. 190 respectively. Conclusions Lauroyl indapamide is a weak acid with lipophilic property.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2005年第5期335-337,共3页
Journal of Shenyang Pharmaceutical University
关键词
月桂酰吲达帕胺
电离常数
分配系数
lauroyl indapamide
ionization constant
partition coefficient
