单糖活性给体合成方法的改进

Improvement of synthetic method of monosaccharide donor

目的改进单糖给体构件块的合成方法。方法单糖经过全苯甲酰基化、溴代、水解,与三氯乙腈生成三氯乙酰亚胺酯的活性给体。结果与结论合成的4种醛基糖的三氯乙酰亚胺酯的活性给体收率达到w=80%左右,其结构经过1H-NMR1、3C-NMR确证。

Objective To improve the synthetic method of monosaccharide donor moiety. Methods Four monosaccharide trichloroacetimidates donors were prepared through benzoylation, bromination, hydrolysis, and addition with trichloroacetonitrile in about 80 % yield. Rusults and Conclusions All products were determined by ^1H-NMR and ^13C-NMR. This simple method provides high yield in preparation of monosacchride donors with aldoses.