2198例液基细胞学宫颈癌筛查的临床分析

Clinical analysis of ziquid-based cytology in 2198 cases of cervical cancer screening

目的:评价Auto Cyte PREP液基细胞学对宫颈癌筛查的临床价值。方法:取2 198例受检者的宫颈脱落细胞作液基薄片细胞学检查,细胞学诊断采用TBS分级系统,阳性诊断包括鳞状上皮内低度病变(LSIL)及以上病变。对于意义不明的不典型鳞状细胞(ASCUS)及以上的受检者行阴道镜活检,并将两种结果作对照。结果:Auto Cyte PREP液基细胞学标本满意度高,检测的敏感性、特异性和准确性分别达到81.6%、91.4%和87.7%,对鳞状细胞癌(SCC)、鳞状上皮内高度病变(HSIL)、鳞状上皮内低度病变(LSIL)的分级敏感性分别为100.0%(10/10)、85.9%(61/71)、77.9%(106/136)。细胞学与组织学级别基本达到一致。结论:液基细胞学应用于宫颈癌筛查能明显提高标本质量和宫颈异常细胞诊断的准确性,尤其是对HSIL。

Objective： To evaluate the clinical value of Auto Cyte PREP Thin - layer Cytology Test for cervical creinoma screening. Methods： This study was performed on 2 198 women with cervical diseases consulting in the Department of Obstetrics and Gynecology of the Union Hospital in Wuhan, Hubei province. Cervical samples were collected into a liquid buffer and utilized for Auto Cyte PREP cyto- logical screening. Those whose samples were classified as ASCUS or above were instructed to do subsequent colposcopic biopsies. Results： The specimen adequacy of the Auto Cyte PREP slides was good, The sensitivity, specificity and accuracy of the owerall detection were 81. 6% , 91. 4% and 87. 7% respectively. The sensitivity of SCC, HSII, and LSIL was 100% , 85. 9% and 77. 9% respectively. The grades of cytology, agreed to those of histology roughly. Conclusion ： The Auto Cyte PREP cytology improves the quality of preparation greatly and demonstrates a high accuracy for the detection of abnormal squamous intraepithelial lesions, especially for high - grade squamous intraepithelial lesions.