贲门癌根治性全胃切除术后TPN支持对机体免疫功能的影响

Effects of Postoperative TPN on Immunocompetence in Patients with Cardia Carcinoma

对１７例贲门癌患者施行根治性全胃切除术（ＲＴＧ），术后随机分为对照组（非ＴＰＮ组）、静脉营养组（ＴＰＮ组），分别在术前和术后９天检测患者外周血的ＮＫ细胞活性和Ｔ细胞亚群。结果显示：ＲＴＧ术后ＴＰＮ支持能使患者ＮＫ细胞活性、细胞、细胞、比值较非ＴＰＮ组显著升高（Ｐ＜０．０５）。提示术后营养支持能改善患者的免疫功能。

Seventeen malnourished patients with cancers of cardia underwent radical total gastrectomy(RTG)were randomly divided into TPN group (n=9) and non-TPN group (n=8). NK cell activity and T cell subsets were determined preoperatively and on the 9th postoperative day. The results showed that the NK cell activity, and ratio were all significantly higher in TPN group than in non-TPN group after RTG(P< 0. 05). In conclusion, postoperative nutritional support including fat emulsion could improve the patients' immune function.