单克隆抗体检测患者粪便中癌相关抗原对消化道癌诊断的价值

Diagnostic Significance of Fecal TAA Assay with Monoclonal Antibody in Digestive Tract Cancer Patients

以消化道癌单克隆抗体，用酶免疫──醋酸纤维薄膜电泳法检测消化道癌、非消化道癌、肠炎、正常人粪便中癌相关抗原。结果表明：对应抗原在大肠癌、食管癌、胃癌、贲门癌患者粪便中的平均含量显著高于非消化道癌、肠炎和正常对照组。其阳性率分别为７７．６３％、５７．１４％、６０％、６１．５４％、１１．５３％、１１．７６％、０，尤其是直肠癌中８例早期（ＤｕｋｅｓＡ）患者均为（＋）。此法为早期诊断提供了简便可行的新手段。

The tumor associated antigen(TAA) in feces was assayed by enzymoimmuno-electrophoresis,using acetate film and anti-digestive tract tumor specific monoclonal antibody.The results showed that significant higher mean levels of TAA were observed in patients with cancers of colon,esophagus,stomach and cardia than those in patients with extraenteral cancer,enteritis or normal individuals.The TAA positive rates in these two groups of patients were 77. 63%, 57.14%,60%,61.54% and 11.53%, 11.76%,O respectively.What is more was that in the 8 cases of early rectal cancer,the feeal TAA was positive. It is suggested that the fecal TAA assay may be a simple and feasible method in early diagnosis of digestive tract cancers.