亚低温对中重度脑梗死患者血管内皮细胞功能的影响

Effects of mild hypothermia on endothelial cell of cerebral vessels in patients with moderate or severe cerebral infarction

目的研究亚低温对中、重度脑梗死患者血管内皮细胞功能包括内皮素(ET)、一氧化氮(NO)及血管性血友病因子(vWF)的影响。方法将60例患者随机分为亚低温组(30例)和对照组(30例),亚低温组在常规药物治疗的基础上加用亚低温处理,对照组仅给予常规药物治疗。2组患者治疗前及治疗15d后均采用中国卒中量表(CSS)进行评分;同时于治疗前、后分别对2组患者血浆及脑脊液中的ET、一氧化氮合酶(NOS)及vWF含量进行检测。结果亚低温组经治疗后,其ET及vWF含量均较治疗前及对照组明显降低(P<0.05或0.01),而NOS含量均较治疗前及对照组明显增高(P<0.05),同时亚低温组的CSS评分也明显低于对照组(P<0.01)。结论亚低温治疗具有内皮细胞保护功能,对中、重度脑梗死患者的脑功能恢复具有促进作用。

Objective To study the effects of mild hypothermia on endothelial cell of cerebral vessels in patients with moderate or severe cerebral infarction. Methods Sixty patients with moderate or severe cerebral infarction were divided into 2 groups： a mild hypothermia group （30 cases） and a non-mild hypothermia group （30 cases）. Endothelin （ET）, endothelial nitric oxide synthases（eNOS） and yon Willebrand factor（vWF） were tested with RIA or ELISA. All the patients were treated with routine medication, in addition, those in mild hypothermia group were also treated with mild hypothermia. Results The ET and vWF levels of serum and cerebrospinal fluid （CSF） in patients of mild hypothermia group were significantly lower than those of non-mild pothermia group （P 〈 O. 05 ,P 〈 O. O1 ）, while the NOS levels were significantly higher （P 〈0.05 ）. Compared with those in no mild hypothermia group, the scores of CSS in mild hypothermia group were lowered significantly （ P 〈 0. O1 ）. Conclusion The mild hypothermia had a good and safe therapeutic effect on protecting endothelial cell and was significantly favorable for moderate or severe cerebral infarction.