慢性乙型肝炎血清及肝组织病毒学标志与病理损伤的关系

Correlation of pathology in chronic hepatitis B to viral markers in serum and hepatic tissue

目的探讨慢性乙型肝炎(CHB)患者血清及肝组织病毒学标志与肝组织病理损伤的关系。方法对647例CHB患者血清病毒学标志HBsAg、HBsAb、HBeAg、HBeAb、HBcAb、HBVDNA及其中418例肝细胞病毒学标志HBsAg、HBcAg的表达与肝组织病理损伤进行对比分析。结果CHB患者血清及肝组织病毒学标志与肝组织病理损伤密切相关。结论血清HBsAg、HBeAb、HBcAb阳性,HBVDNA阴性的患者肝组织炎症及纤维化程度较轻;HBVDNA与肝组织炎症分级及纤维化分期无明显相关;肝细胞HBsAg、HBcAg均阴性表达的肝组织炎症及纤维化程度较重。

Objective To investigate the relation of the viral markers in serum and those expressed by hepatocytes to pathological lesions of hepatic tissue in patients with chronic hepatitis B. Methods The relation of viral markers including HBsAg, HBsAb, HBeAg, HBeAb, HBcAb and HBV DNA in serum of 647 patients with chronie hepatitis B and HBsAg, HBcAg expressed by hepatocytes in 418 of these patients to pathological lesions of hepatie tissue was determined. Results Viral markers in serum and those expressed by hepatocytcs in patients with chronie hepatitis B were closely correlated with pathological lesions of hepatic tissue. Conclusions The degree of inflammation and fibrosis in hepatic tissue is milder in serum HBsAg, HBeAb, HBcAb positive and HBV DNA negative patients but more serious in those with negative hepatocytic expression of HBsAg and HBcAg. HBV DNA is not significantly associated with pathological lesions of hepatic tissue.