口服超常剂量降压药治疗急性主动脉夹层并发高血压的临床观察

Effects of hypotensive drugs with supernormal dosage on patients with acute dissection of aorta

目的:评价口服超常剂量降压药治疗急性主动脉夹层并发高血压患者的临床疗效及不良反应。方法:49例急性主动脉夹层并发高血压患者,根据使用降压药的剂量分为常规剂量组和超常剂量组。记录2组患者治疗前后血压、心率以及药物不良反应的发生情况。结果:常规剂量组与超常剂量组的患者治疗后血压、心率较治疗前均叫显下降;2组不良反应的发生率相似。结论:用超常剂量的降压药治疗主动脉夹层并发高血压是安全而有效的。

Objective：To evaluate the clinical and adverse effects of hypotensive drugs with supernormaldosage on patients diagnosed with acute dissection of aorta and hypertension. Method：Forty nine patients with acute dissection of aorta and hypertension were randomly divided into two groups： Group routine dosage （ n=14） and Group supernormai dosage （ n= 35）. Blood pressure, heart rate, and adverse effects before and after treatment were recorded. Result： Blood pressure and heart rate were significantly decreased after treatment in both Group routine dosage and Group supernormai dosage, but there was no statistical difference in the incidence of adverse effects between the two groups. Conclusion：Hypotensive drugs with supernormai dosage are safe and effective to patients with acute dissection of aorta and hypertension.