血浆同型半胱氨酸与原发性高血压的流行病学研究

The epidemiologic study of the relationship between plasma homocysteine and hypertension

目的:探讨血浆同型半胱氨酸(HCY)与原发性高血压(EH)的关系以及与危险因素的相关性。方法:采取整群随机抽样的方法抽取调查样本,选择徐州市大屯社区369例中年居民为调查对象,运用病例对照研究方法,通过酶联免疫吸附法测定血浆HCY水平,并作统计学处理。结果:①EH组血浆HCY水平高于对照组(P<0.05),EH组高HCY血症(血浆HCY浓度>15μmol)为36.2%,对照组为21.6%,差异有统计学意义(P <0.05)。②血浆HCY水平与三酰甘油、收缩压、舒张压呈正相关(r=0.108-0.139,P<0.05),与载脂蛋白A 呈负相关(r=-0.189.均P<0.05),但其相关性较弱,且血浆HCY水平与其他危险因素之间未发现明显相关性。结论:血浆HCY不仅是EH发生的一个危险因素,可能还是一个独立的危险因素。检测血浆HCY水平对EH的预防、诊疗具有重要临床价值。

Objective：To study the relationship between plasma homocysteine and hypertension. Method：Three hundreds and sixty nine middle age residents of Datun Xuzhou were investigated. Plasma homocysteine was measured by using enzyme immunoassay method. Statistical analysis was done to all measured parameters. Result： ① The homocysteine levels in hypertension group was significantly higher than those in control group （ P 〈0.05）. ② There were significantly positive correlation between homocysteine levels and systolic blood pressure, diastolic blood pressure, triglyceride（ r=0. 108-0. 139, P 〈0.05） and negative correlation between homocysteine levels and apolipoprotein-A level （ r =-0. 189, P 〈0.05）. Conclusion： Hyperhomocysteinemia is a risk factor for hypertension.