血浆脂联素水平与2型糖尿病及其代谢综合征的关系

Relationship Between Plasma Adiponectin Level and Metabolic Syndrome in Patients With Type 2 Diabetes

目的了解2型糖尿病及其合并代谢综合征患者中血浆脂联素水平的状况。方法对2型糖尿病合并代谢综合征组49例、2型糖尿病非代谢综合征组54例、正常对照组35例,测定其血浆脂联素水平,同时测定糖尿病患者的血糖、血压、血脂、C肽水平,比较3组间血浆脂联素平均水平、低脂联素血症发生率,分析其影响因素。结果糖尿病合并代谢综合征组、糖尿病非代谢综合征组及正常对照组血浆脂联素水平分别为(4.14±3.08)μg/ml、(6.65±4.55)μg/ml和(16.37±3.03)μg/ml,组间均有显著差异(P<0.05);3组中低脂联素血症发生率分别为69.4%、44.4%及0%,均有显著差异(P<0.05)。在糖尿病患者中,血浆脂联素与收缩压呈负相关(P<0.001)。结论2型糖尿病患者血浆脂联素水平明显降低,合并代谢综合征者降得更低,提示血浆脂联素与代谢综合征的发生发展可能有密切关系。

Objectives： To investigate the state of plasma adiponectin levels in type 2 diabetic patients with metabolic syndrome. Methods： Forty-nine type 2 diabetic patients with metabolic syndrome, 54 type 2 diabetic patients without metabolic syndrome and 35 healthy subjects were investigated. Their plasma adiponectin level was assayed. The levels of blood pressure, plasma glucose, lipids and C-peptide were measured. Plasma adiponectin levels and incidence of hypoadiponectinemia between the three groups were compared, and the factors affecting plasma adiponectin were analyzed. Results：The plasma adiponectin levels in the above three groups were 4. 14±3.08μg/ml,6.65±4.55μg/ml和16.37±3.03μg/ml, respectively. The differences between the three groups were statistically significant （P〈0.05）. The incidence of hypoadiponectinemia of the three groups was 69.4% ,44.4% and 0% , respectively （P〈0.05）. The level of plasma adiponetin was negatively related to the systolic pressure in type 2 diabetic patients （P〈0.001）. Conclusion ： The level of plasma adiponectin in type 2 diabetic patients is significantly decreased, especially in the type 2 diabetic patients with metabolic syndrome. The results suggest that the level of plasma adiponectin may be closely related to metabolic syndrome in type 2 diabetic patients.