摘要
强直性脊柱炎(ankylosing spondylitis,AS)是一种常见的高度遗传的风湿类疾病。至20世纪70年代以来,越来越多的证据表明HLA-B27是AS最主要的易感基因。然而,全基因组扫描和关联分析等研究发现在HLA以外的区域仍存在AS的易感区域,大量的证据显示在HLA区内外有许多基因与AS的发病有关。文章主要综述了与AS相关的易感基因以及它们的研究现状。
Ankylosing spondylitis (AS) is a highly heritable, common inflammatory rheumatic disease. Since 1970s, evidence has increasingly pointed to HLA-B27 as the major gene involved in susceptibility to AS. However, genome-wide scan and association studies have shown, in addition to HLA, regions outside the HLA are involved in susceptibility to AS. Furthermore, there is compelling evidence that non-B27 genes, either within or outside the HLA, are involved in disease aetiology. This review mainly summarized different genes associated with AS, and the current progress in this exciting area.
基金
国家863计划(国家高技术研究发展计划项目)(编号:2001A213111)~~
关键词
强直性脊柱炎
易感性
全基因组扫描
关联分析
连锁分析
ankylosing spondylitis
susceptibility
genome-wide scan
association analysis
linkage analysis