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EMT在胚胎发育及肿瘤发生过程中的生物学作用 被引量：5

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摘要 上皮细胞间质转化(epithelial-mesenchymal transition,EMT)描述的是上皮细胞在与周围间质的相互作用过程中逐渐获得了某些间质细胞所特有的性状的现象。它不仅存在于多细胞生物的胚胎发生过程中,同时也存在于多种慢性疾病(如肾纤维化)的发病以及肿瘤的发展过程。它以上皮细胞极性的丧失及其间质特性(成纤维细胞样的外形,波形纤维蛋白、Snail、骨桥蛋白基因的表达)的获得为主要特征,并且与肿瘤细胞的原位侵袭和远隔转移有着密切的关系。本文综述了EMT的研究现状及其与肿瘤的发生、发展及预后的关系及表达情况,为EMT的深入研究做好铺垫。
作者 宁亮 罗勇 贺大林
机构地区 西安交通大学泌尿外科研究所
出处 《现代泌尿外科杂志》 CAS 2005年第5期308-310,共3页 Journal of Modern Urology
关键词 上皮细胞间质转化(EMT) 胚胎发育 慢性疾病 肿瘤发生
分类号 R730.2 [医药卫生—肿瘤]
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参考文献30

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  • 2Gotzmann, Josef. Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-β1 and Ha-Ras: steps towards invasiveness [J]. Mutation Research/Reviews in Mutation Research, 2004, 566(1):9-20.
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同被引文献49

  • 1李伟,辛殿祺,郭应禄.前列腺癌PC-3细胞中Wnt信号通路与TGF-β信号通路相互调节[J].中华泌尿外科杂志,2006,27(S1):59-62. 被引量：6
  • 2刘厚奇.器官发育中细胞转型的机制和意义[J].第二军医大学学报,2005,26(4):349-351. 被引量：3
  • 3吕宝忠.肿瘤干细胞研究进展[J].肿瘤,2006,26(1):1-2. 被引量：1
  • 4Hall CL, Kang S, MacDougald OA, et al. Role of Wnts in prostate cancer bone metastases. J Cell Biochem,2006,97 (4) :661 - 672.
  • 5Chesire DR, Isaacs WB. Beta -catenin signaling in prostate cancer: an early perspective. E ndocr Relat Cancer,2003,10 (4) :537 - 560.
  • 6Katoh M ,WNT/PCP signaling pathway and human cancer (review). Oncol Rep,2005,14 (6) : 1583 - 1588.
  • 7Veeman MT, Axelrod JD, Moon RT. A second canon. Functions and mechanisms of beta - catenin - independent Wnt signaling. Dev Cell, 2003,5 ( 3 ) : 367 - 377.
  • 8Liu You hua. Epithelial to Mesenchymal Translation in Renal Fibrogenesis : Pathologic Significance, Molecular Mechanism, and Therapeutic intervention. J Am Soc Nephrol,2004,15 ( 1 ) : 1 - 12.
  • 9Boyer B, Valles AM, Edme N. Induction and regulation of epithelial - mesenchymal transitions. Biochem Pharmacol. 2000,60 ( 8 ): 1091 - 1099.
  • 10Wijnhoven BP, Dinjens WN, Pignatelli M.. E - cadherin - catenin cell -cell adhesion complex and human cancer. Br J Surg,2000,87(8):992 - 1005.

引证文献5

二级引证文献8

现代泌尿外科杂志
2005年 第5期

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