游泳运动对大鼠纹状体、下丘脑多巴胺的含量及其代谢的影响

Effects of Swimming on DA Concentration in Hypothalamus、Corpus Striatum of Rats

目的:探讨游泳运动对大鼠纹状体、下丘脑(DA)内多巴胺的含量及其代谢的影响。方法:选取72只雄性SD大鼠,随机分成6组:安静对照组(A)、一次性力竭游泳运动组(B)、安静+水环境组(C)、游泳耐力训练组(D)、水环境组(E)、游泳耐力训练后一次性力竭游泳运动组(F)。D组按照耐力训练方案进行负重训练,每周5次,持续7周。所有大鼠一起断头处死,各组交叉进行,迅速取出脑组织(纹状体、下丘脑)进行多巴胺浓度和单胺氧化酶B(MAO-B)活性的测试。结果:一次性力竭运动或游泳训练对下丘脑中DA含量或MAO-B活性的影响无明显影响,而纹状体DA浓度在一次性力竭运动尤其是游泳训练后都明显升高(P<0.05),MAO-B也有升高的趋势。结论:一次性力竭运动尤其是游泳耐力训练使DA的浓度和MAO-B活性增加,其合成和分解代谢都增加,提高了DA的转换率,以适应运动的需要,有利于改善脑机能,延缓运动疲劳,是适应运动的表现。

Objective：To explore the effects of swimming on DA Concentration in hypothalamus, corpus striatum of rats. Methods： Seventy-tow SD rats wear divided into six groups：sedentary control group （ A ） ,acute swimming group （ B ） ,once water control group （ C ） ,swimming training group （ D ） ,long water control group （ E ） ,swimming training and acute swimming group （ F ）. B and F rats are killed immediately after swimming following the fnal experiment. All of other rots are also killed at the same time and take out of the brain quickly. Then estimate the DA concentration and MAO-B activity in corpus striatum,corpus striatum of rats. Results：DA in corpus striatum is significantly increased after acute swimming and especially after swimming training, and MAO-B activity also has the tendency of increase. But the DA and MAO-B level in hypothalamus is not significantly influenced. Conclusion： Acute swimming or swimming training increases the synthesis and metabolism of DA in corpus striatum, and the DA turnover rate is rised. It is help to improve the brain function and delay the exercise-induced central fatigue.