中医综合疗法治疗特发性肺间质纤维化32例临床观察

Clinical Observation on 32 Cases of Idiopathic Pulmonary Interstitial Fibrosis Treated with TCM Comprehensive Therapy

目的:探讨中医综合疗法治疗特发性肺间质纤维化的优势。方法:将肺间质纤维化患者随机分为中医综合治疗组和百令胶囊组各32例,另设空白对照组6例,中医综合治疗组用中药协定方加减内服外敷综合治疗,百令胶囊组单用百令胶囊,观察并比较各组症状评分、动脉血氧及肺功能指标在治疗前后的变化。结果:中医综合治疗组在用药前后症状评分、动脉血氧及肺功能弥散指标方面有所改善,与百令胶囊组比较差异有显著性(P<0.05),与空白对照组比较症状评分、肺功能弥散指标改善非常显著(P<0.01),肺总量指标也有明显改善(P<0.05)。结论:中医综合疗法可以改善特发性肺间质纤维化患者的自觉症状、缺氧状态和肺功能弥散指标,是较单一百令胶囊更为有效的治疗方法。

To find the advantage of TCM comprehensive therapy in treatment of idiopathic pulmonary interstitial fibrosis （IPIF）. Methods： 70 cases of IPIF were divided into a TCM treatment group （n= 32）,a Bailing Capsule group （n= 32） and a blank control group（n= 6）. They were treated by internal administration and external application of a modified stipulated prescription of Chinese medicine, simple Bailing Capsule and no treatment, respectively. Changes of symptom scores, blood oxygen and pulmonary function indexes before and after treatment were observed and compared. Results：After treatment, symptoms scores,blood oxygen and the defuse index of pulmonary function in the TCM treatment group improved with a significant difference as compared with Bailing Capsule group （P〈0. 05）,and there was very significant difference in improvement of the symptom scores and the diffuse index of pulmonary function,and the total lung volume between the TCM treatment group and the blank control group （P〈0.05 or P〈 0. 01）. Conclusion： TCM comprehensive therapy can improve objective symptoms, and hypoxia and diffuse index of pulmonary function,and it is a better effective therapy than Bailing Capsule for the patient of IPIF.