肾血管性高血压时脑与肠系膜动脉壁CGRP能神经纤维分布的变化

Changes of the CGRP-containing nerve fibers in the cerebral arteries and the mesenteric arteries of renal vascular hypertension

目的:观察肾血管性高血压时中枢与外周动脉壁CGRP(calcitoningene-relatedpeptide)能神经纤维分布的变化,探讨CGRP与肾血管性高血压的关系。方法:应用免疫组织化学SABC法观察双肾双夹肾血管性高血压大鼠不同时期(术后4、8、12周)脑动脉壁和肠系膜动脉壁CGRP能神经纤维密度的变化。结果:高血压各组CGRP能神经纤维密度均高于对照组,有显著性差异(P<0.01);高血压组12周CGRP能神经纤维密度高于高血压组4周,有显著性差异(P<0.01);对照组CGRP能神经纤维较纤细,多沿血管长轴走行,高血压组CGRP能神经纤维较粗大,呈网状分布。结论:随着血压的升高,中枢与外周动脉壁CGRP能神经纤维密度增加,这可能是机体产生的一种代偿性保护机制,起着调节血压的作用。

Objective： To observe the changes ofCGRP （calcitonin gene-related peptide）-containing nerve fibers in the cerebral arteries and the mesenteric arteries of renal vascular hypertension, and discuss the relationship between CGRP and renal vascular hypertension. Methods： The changes of CGRP-containing nerve fibers in the cerebral arteries and the mesenteric arteries in different periods （4 weeks, 8 weeks and 12 weeks after operation） in two-kidney, two-clip （2K2C） renal vascular hypertensive rats were observed by using SABC immunohistochemical technique. Results： The densities of CGRP -containing nerve fibers in the cerebral arteries and the mesenteric arteries were higher in hypertension groups compared with control groups（P〈0.01）. In hypertension groups, the densities of CGRP-containing nerve fibers in the cerebral arteries and the mesenteric arteries were higher in 12 weeks group compared with 4 weeks group （P〈0.01）. CGRP-containing nerve fibers were thinner and run longitudinally along the walls of the arteries in control groups, while in hypertension groups, CGRP-containing nerve fibers were thicker and often constituted mesh-work on the wall of the arteries. Conclusions： The results suggest that the density of CGRP -containing nerve fibers increased with blood pressure in the peripheral and the center vascular wall, which is likely playing a compensatory depressor role to partially counteract the increased blood pressure.