超微量肝素皮下注射治疗新生儿硬肿症疗效观察

Observation on the healing effect in treating the newborn babies for their sclerema by means of hypodermic injection with minidose heparin

目的初步观察超微量肝素在新生儿硬肿症治疗上的疗效.方法将新生儿硬肿症101例随机分成两组,治疗组52例,对照组49例.对照组采用暖箱快速复温,抗感染,纠酸,热卡供应及支持治疗,复方丹参2～5 ml/d以及低分子右旋糖酐10 ml/(kg·d)静脉滴注,对于中、重度硬肿病例加用多巴胺0.5 mg/(kg·次)及酚妥拉明0.25～0.5 mg/(kg·次)置入5%葡萄糖10～20 ml中,以多巴胺10μg/(kg·min)的速度静点或微量输液泵缓慢滴注.治疗组在以上治疗的基础上加用肝素5～8 U/(kg·次),每6 h或12 h于硬肿处皮下注射一次.结果治疗组显效29例,有效16例,无效7例.对照组显效13例,有效21例,无效15例,经统计学处理有非常显著性差异(P＜0.01).结论超微量肝素皮下注射治疗新生儿硬肿症疗效较好,值得在基层医院推广.

Objective To observe the effect of using hypodermic injection with minidose heparin to treat the newborn babies for their sclerema . Methods 101 cases of newborn babies with sclerema were randomly divided into two groups treatment group （52 cases） and control group （49 cases）. Many possible ways were tried on the 49 cases. Besides all the ways used for the control group, hypodermic injection with minidose heparin was also included for the treatment group. Results According to the effects of the two groups, there was statistic difference （P〈 0.01）. Conclusion The method of using hypodermic injection with minidose heparin to treat the newborn babies for their sclenema is effective. It is worth trying in the hospitals at grass-root level.