去炎舒松用于预防隆乳术后包膜挛缩的实验研究

The experimental researches on the use of triamcinolone acetonide for the prevention of implant capsular contracture

目的探讨去炎舒松用于抑制假体隆乳后包膜挛缩的方法。方法20只新西兰大白兔,平均分为2组,每组将10ml硅凝胶假体1个随机置入兔背部肌肉下,将有许多侧孔远端为盲端的扩张器导管跨越假体顶部,与导管相连的注射壶置于皮下。分别在假体置入1、2、3个月时,向对照组经注射壶注入3ml生理盐水,向实验组注入去炎舒松10mg3ml。在6个月时观察测量记录包膜挛缩情况,Baker评分,压缩实验,包膜切开后裂开最大宽度的测定,包膜厚度的比较,取包膜样本切片进行HE染色和天狼猩红染色,镜下观察比较包膜特点。结果生理盐水组Baker评分、包膜裂开最大宽度、包膜厚度明显高于去炎舒松组(P<0.01)。生理盐水组假体压缩率明显低于去炎舒松组(P<0.01)。去炎舒松组包膜较生理盐水组薄,胶原排列规则、疏松。结论去炎舒松通过特制的导管给药能有效地降低隆乳术后包膜挛缩。

Objective To explore the use of triamcinolone acetonide for the prevention of implant capsular eontraeture. Methods 20 rabbits were randomly individed into 2 groups of 10 animals each. Every 10 ml silicone implant was implanted beneath the panniculus carnosus muscle of one rabbit. At the same time, a modified expander catheter was mounted on the implant. This catheter has many lateral holes and the end was blind. Triamcinolone acetonide （ 10 mg/3 ml） was infused through the expander pot and catheter as the experimental groups. （In the other hand, 3 ml saline was used as the control group at 1,2,and 3 months. At 6 months, measures related to contracture and capsular histology examinations were performed on anesthetized animals. Results Baker scores, capsular incision width and capsular thickness of the saline groups were evidently higher than that of triamcinolone acetonide groups （ P 〈 0.01 ）. Implant compression of the saline groups was evidently lower than that of triameinolone aeetoaide group. Histology revealed a thinner capsules and less fibrous tissue deposition around the triameinolone aeetonide group, as compared with saline group. Conclusions It is effective to deliver triamcinolone acetonide to reduction of capsnlar eontracture through the catheter and its pot.