牛磺酸对兔肺缺血再灌注内皮素-1生成的影响

Influence of Taurine on Production of Endothelin-1 in Rabbits' Lungs Induced by Ischencia-reperfusion Injury

目的:研究牛磺酸对兔缺血再灌注肺脏内皮素-1(endothelin-1,ET-1)生成的影响。方法:24只健康家兔随机分为三组:假手术组、生理盐水组(缺血再灌注+生理盐水组)、牛磺酸组(缺血再灌注+牛磺酸组)。观察左肺再灌注0、60、90、120min各时间点血浆ET-1和实验结束时肺湿/干比重、肺水含量的变化及肺组织的病理改变。结果:与假手术组相比,生理盐水组血浆ET-1、肺湿/干比重、肺水含量及肺组织的病理改变均明显升高/加重,而牛磺酸组则无明显改变。结论:肺缺血再灌注损伤可以引起肺脏内部合成和分泌ET-1,ET-1参与了肺缺血再灌注损伤;牛磺酸可抑制肺内部分合成ET-1并保护缺血肺组织。

Objective： To explore the influence of taurine on production of endothelin-1 in rabbits＇lungs induced by ischencia-reperfusion （I/R） injury. Methods： 24 healthy rats were divided randomly into false operation group, physioloyic saline group （I/R＋ physioloyic saline） and taurine group （I/R＋taurine）. The change of ET-1 after reperfusion of left lung for 60, 90, and 120 minutes were observed. The variation of lung wet/dry ratio, water content and pathology of lung tissue were also investigated. Results： Compared with that of false operation group, the ET-1 level, lung wet/dry ratio, lung water content of physioloyic saline group fibrosis were obviously increased. There was no significant difference in taurine group. Conclusion： lschencia-reperfusion injury will lead to the pro- duction oF ET-1 in the injured lung. Taurine can inhibit the producntion of ET-1 and protect the ischemic lung.