消化道癌P-糖蛋白的表达及与化疗反应的关系

P-glycoprotein expression in carcinoma of digestive tract and the role in chemotherapy

目的:研究P糖蛋白(Pgp)在消化道常见癌组织中的表达,以指导临床化疗。方法:收集我院2002年1月～2002年10月术前未经治疗的消化道癌切除标本150例,以SP免疫组化方法检测其Pgp表达。结果:胃腺癌、大肠腺癌Pgp表达阳性率及强度均高于食管鳞癌,差异有统计学意义,P<0.01。Pgp阳性表达与消化道癌患者的性别、年龄、癌分化程度及淋巴结转移均无关,P>0.05。结论:Pgp在消化道常见癌组织中表达增高,检测消化道癌(尤其是胃肠道腺癌)的Pgp表达对选择合理的化疗方案和判断预后有重要作用。

OBJECTIVE： To ascertain the frequency of P-gtycoprotein （P-gp） expression in three, common carcinomas of digestive tract in order to direct elinical therapy.METHODS： One hundred and fifty surgically resected tumor specimens confirmed pathologically to be malignant digestive tract carcinomas from preoperatively untreated carcinoma patients were studied. Expression of P-gp was examined by SP immunohistochemistry. RESULTS： The positive rate and intensity of P-gp expression in gastric and colorectal adenocarcinomas were higher than those in squamous cell carcinoma of esophagus. the difference was significant,P〈0. 01, No correlation was observed with gender.age. differentiation and lymph node metastasis.P〉0. 05. CONCLUSIONS： Primary P-gp expression is related to the frequent occurrence in common carcinomas of digestive tract. Examining P-gp expression in digestive carcinomas, especially gastric and colorectal adenocarcinomas, plays an important role in orientating the cancer treatment and predicting prognosis.