反相微乳液的研究及其在淀粉微球制备的应用(英文)

Study on an Inverse Microemulsion and Its Application for Preparing Starch Microsphere

淀粉来源广泛,价格低廉,具有很好的生物兼容性和降解性,近年来,以淀粉为原料,开发新产品或新应用途径,已成为研究的热门课题。本文首先提出以环己烷和氯仿为油相,Span80和Tween60作为复合乳化剂,碱性淀粉溶液为水相的反相微乳液,并以此制备粒度分布较均匀的,满足药物控释要求的淀粉微球。研究反应条件对微球粒度的影响,并应用SPSS统计工具推导出微球粒度与搅拌速度、油水相体积比、淀粉溶液浓度、表面活性剂用量及交联剂用量等因素之间的多元线性回归方程。

A new stable miciroemulsion, consisting of cyclohexane and chloroform with Span80 and Tween60 as complex surfactant, was found and could be used for preparation of starch microspheres. The effects of main factors affecting starch microsphere size and size distribution, i.e. stirring speed, initial volume ratio between oil phase and aqueous phase etc, were investigated based on single-factor studies, The multi-factor linear equation was deduced by SPSS.