刺五加提取物抗疲劳作用的研究

Study on Anti-fatigue Function of Acanthopanax Senticosus Extract

目的研究刺五加提取物的抗疲劳作用。方法将雄性BALB/C小鼠按体重随机分为4组:空白对照组和200、400、700mg/kgbw3个刺五加提取物剂量组。在给予受试物15d后测定各组的小鼠负重游泳的持续时间,10min无负重游泳的血乳酸水平(静息值、即刻值、泳后20min值)及肝糖原含量的变化。结果:400mg/kgbw,700mg/kgbw的刺五加提取物能提高肝糖元的储备(p<0.01);700mg/kgbw刺五加组游泳时间长于空白对照组(p<0.05);700mg/kgbw刺五加组血乳酸降低比值高于对照组(p<0.01)。结论:刺五加提取物具有抗疲劳作用。

Objective To study the anti-fatigue effect of Acanthopanax senticosus extract. Methods The male mice of BALB/ c were randomly divided into four groups according to their body weight： a solvent control group, Acanthopanax senticosus extract 200, 400 and 700mg/kgbw group. The mice were administered respectively with water and 200,400, 700mg/kgbw Acanthopanax senticosus extract. After 15 days, the forced swimming test, blood lactic acid and hepatic glycogen content were determined. Results： The swimming time of mice in 700mg/kg.bw group was significantly prolonged as compared with that in control group （p 〈 0.05）. 400mg/kgbw, 700mg/kgbw groups could obviously increased hepatic glycogen storage （p 〈 0.01）. 700mg/kg.bw groups could significantly accelerate lactic acid clearance after mice swimming （p 〈0.01） .Conclusion： Acanthopanax senticosus extract has an anti-fatigue effect.