黑桑椹对高脂血症大鼠的降脂作用研究

Hypolipidemic Effects of Black Mulberry Dried Fruit on Diet-induced Hyperlipidemia in Rats

目的研究黑桑椹对高脂血症大鼠脂质代谢的影响。方法普通基础饲料加10%猪油、1%胆固醇,0.5%胆酸钠组成高脂饲料。高脂饲料中添加10%的黑桑椹果粉饲喂Wistar大鼠(桑葚组),4w后与单饲高脂饲料的大鼠(高脂组)对比血脂和肝脂水平。结果与高脂组比较,桑葚组大鼠血清和肝脏的胆固醇、甘油三酯含量均显著降低(p<0.01),血清低密度脂蛋白胆固醇和致动脉硬化指数也明显下降(p<0.01),而高密度脂蛋白胆固醇和抗动脉硬化指数显著升高(p<0.01);结论黑桑椹果粉对高脂血症大鼠具有显著的降脂、抗动脉粥样硬化作用。

Objective To investigate the effect of Black Mulberry Fruit（Morus alba L.） on lipia metabolism in rats fed high-fat diet. Methods Wistar rats were randomly divided into 3 groups and fed on basal diet, high-fat diet （basal diet with 10% lard and 1% cholesterol）, test diet （high-fat diet with 10% black mulberry dried fruit） for 4 weeks. Results The results showed for hyperlipidemia rats, the high-fat diet with10% black mulberry dried fruit 1 can markedly decrease the serum TC, TG, LDL-c, AI and liver TC, TG, meanwhile can increase serum HDL-c and AAI. Conclusion Black mulberry dried fruit has effects on hypolipidemic and anti-atherosolerosis.