司丙红霉素对大鼠的长期毒性

Long-term toxicity of erythromycin propionate-N-acetylcysteinate in rats

目的:考察连续给予司丙红霉素(EPAC)对大鼠的毒性反应。方法:健康SD大鼠分别按体重随机分为低、中、高剂量组和蒸馏水组。低、中、高剂量组给药量分别为75,150和300mg·kg-1,连续灌胃给药90d。结果:司丙红霉素300mg·kg-1剂量组大鼠进食量减少,体重减轻,并伴有呕吐;150和300mg·kg-1剂量组大鼠血清总胆红素(T-Bil)及天冬氨酸转氨酶(AST)升高;300mg·kg-1剂量组血清丙氨酸转氨酶(ALT)升高。1个月恢复期后,150和300mg·kg-1剂量组各项指标均恢复正常。75mg·kg-1剂量组大鼠各项指标无明显影响。结论:司丙红霉素可引起可逆性毒性反应,大鼠口服司丙红霉素90d的安全剂量为75mg·kg-1。

Objective： To assess the long-term toxicity of erythromycin propionate-N-acetylcy-steinate （EPAC） in rats. Methods：SD rats were randomly assigned to one of four diet groups; each group was orally supplemented either normal diets or diets with EPAC at a dose of 75, 150 or 300mg·kg^- 1 daily for up to 90d, respectively. Results： At the dose of 300mg·kg^- 1, the rats experienced lower appetite, weight loss and vomit as well as abnormal increases of ALT, T-Bil and AST levels. The dose of 150 mg·kg^-1 significantly escalated the serum T-Bil and AST levels. All of the abnormalities recovered in one month after the dosing of EPAC were terminated. No toxicity was observed in the 75 mg·kg^-1 group. Conclusion： Higher dosing of EPAC could produce reversible toxicities in rats.