体重超重对多囊卵巢综合征患者内分泌改变的影响

Impact of Overweight on the Endocrine Changes in PCOS Patients

目的:探讨体重超重对多囊卵巢综合征患者的内分泌改变的影响。方法:检测31例体重超重和102例非超重多囊卵巢综合征患者的内分泌激素和胰岛素敏感性。结果:超重组的雄激素和空腹胰岛素水平显著升高(P<0.05,P<0.01),GIR显著下降(P<0.01),HOMAIR明显升高(P<0.01),超重组胰岛素抵抗的发生率明显高于非超重组,BMI与胰岛素敏感性呈负相关。结论:体重超重的PCOS患者高雄激素血症和胰岛素抵抗都更为严重,对超重PCOS患者的治疗应注重于纠正高雄激素血症和胰岛素抵抗状态。

Objective： To explore the impact of overweight on the endocrine changes in PCOS patients. Methods： The horrnone level and insulin sensitivity were detected in 31 overweight and 102 non-overweight PCOS patients. Results： The serum androgen and fasting insulin levels were significantly higher in overweight group with lower GIR and higher HOMA-IR, when compared to non-overweight group （ P〈0.05, P〈0.01）. The incidence of insulin resistance was higher in overweight group than non -overweight group. BMI was negatively related to insulin sensitivity. Conclusions： Hyperandrogenism and insulin resistance were more obvious in overweight PCOS patients, which should be emphasized in their treatment.