单侧多囊卵巢与多囊卵巢综合征的比较研究

Comparison between Unilateral Polycystic Ovary and Polycystic Ovarian Syndrome

目的:探讨单侧多囊卵巢的临床病理特点及病因。方法:收集单侧多囊卵巢12例,与8例典型多囊卵巢综合征对照比较,分析其临床表现、生化参数、卵泡液中相关激素水平以及卵巢间质细胞超微结构。结果:单侧PCO患者临床表现多样,和典型PCOS比较,单侧PCO出现月经改变和不孕显著减少。单侧PCO组血清PRL和T水平显著高于正常对照组,P<0.05;LH水平显著低于PCOS组,P<0.01。单侧PCO卵泡液中T和INS的水平比正常侧卵巢组显著升高,P<0.01;LH水平显著低于PCOS组,P<0.05。单侧PCO间质细胞粗面内质网、光面内质网不同程度出现扩张,部分粗面内质网有脱粒现象;线粒体出现扩张。结论:单侧PCO是一种不同于PCOS的特殊疾病类型,其临床表现多样,对卵巢生殖和内分泌功能的损害比PCOS轻。单侧PCO与PRL和卵巢局部T异常分泌均有关。单侧PCO间质细胞超微结构改变介乎正常卵巢和典型PC0S之间。

Objective： To explore the clinical- pathologic characterization of unilateral polycystic ovary （PCO） and its relationship with typical polycystic ovarian syndrome （PCOS）. Methods： 12 patients with unilateral polycystic ovary were enrolled and analyzed by symptoms, signs, biochemical parameters in serum and follicular fluid, ultrasonic signs and uitrastructure of ovarian stroma cells compared with typical polycystic ovarian syndrome as well. Results： Patients of unilateral polycystic ovary presented diversely, They showed less menstrual disturbance （ P〈0.05） and infertility （ P〈0.05） compared with typical polycystic ovarian syndrome group. Serum levels of PRL and T in unilateral polycystic ovary group were significantly higher than typical polycystic ovarian syndrome group （both P〈0.05）, while LH was lower than typical polycystic ovarian syndrome group （ P〈0.01 ）. Uitrastructure of unilateral polycystic ovary was similar to transitional polycystic ovarian syndrome, Conclusions. Unilateral polycystic ovary is of a special characterization that different from typical polycystic ovarian syndrome. Its damage to ovarian reproductive and endocrine functions is slighter than typical polycystic ovarian syndrome. Hyperprolactinemia and hyperandrogenism were plunged in pathogenesis of unilateral polycystic ovary. The uitrastructure of stromal cell in unilateral polycystic ovary is mediated between normal ovary and typical PCOS.