藏药云南兔耳草的化学成分研究

Study on Chemical Constituents of Lagotis yunnanensis

从云南兔耳草中分离得到6个化合物,分别鉴定为槲皮素-3-O-β-D-葡萄糖苷(quercetin-3-O-β-D-gluco- side,1),芹菜素-7-甲醚(apigenin-7-methyl ether,2),反式-肉桂酸(E-cinnamic acid,3),顺式-肉桂酸(Z-cinnamic acid,4),反式-对香豆酸(E-p-coumatic acid,5),顺式-对香豆酸(Z-p-coumatic acid,6)。以上化合物均为首次从该植物中分离得到。

Objective：To study the chemical constituents of Lagotis yunnarwnsis W. W. Smith. Methods：Compounds were isolated from the ethanolic extract of the title herb by silicagel column chromatography and polyamide column chromatography,and their structures were identified by physical and chemical evidences and spectral methods. Results：Six compounds were isolated and identified as quercetin-3-O-β-D-glucoside （ 1 ）, apigenin-7-methyl ether （ 2 ）, E-cinnamic acid （ 3 ） , Z-cinnamic acid （ 4 ）, E-p-coumatic acid （ 5 ）, Z-p-coumatic acid （6）. Conclusion ： All the compounds are isolated from this plant for the tirst time.